Pseudomonas aeruginosa PAO1, PA3111 (folC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3111
Name
folC
Replicon chromosome
Genomic location 3491415 - 3492704 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251801.1
GI 15598307
Affymetrix PA3111_folC_at
Entrez 879056
GenBank AAG06499.1
INSDC AAG06499.1
NCBI Locus Tag PA3111
protein_id(GenBank) gb|AAG06499.1|AE004735_6|gnl|PseudoCAP|PA3111
TIGR NTL03PA03111
UniParc UPI00000C60B9
UniProtKB Acc Q9HZA8
UniProtKB ID Q9HZA8_PSEAE
UniRef100 UniRef100_Q9HZA8
UniRef50 UniRef50_Q4KEZ7
UniRef90 UniRef90_A0A022P9Z5

Product

Feature Type CDS
Coding Frame 1
Product Name
folylpolyglutamate synthetase
Product Name Confidence: Class 2
Synonyms dihydrofolate synthetase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.18
Kyte-Doolittle Hydrophobicity Value 0.001
Molecular Weight (kDa) 46.5
Isoelectric Point (pI) 4.99

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 604 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002487 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3111
Search term: folC

Human Homologs

Ensembl 110, assembly GRCh38.p14
folylpolyglutamate synthase [Source:HGNC Symbol;Acc:HGNC:3824]
E-value: 1.5e-25
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
folylpolyglutamate synthase [Source:HGNC Symbol;Acc:HGNC:3824]
E-value: 1.5e-25
Percent Identity: 39.3

References

Mutagenesis of the folC gene encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli.
Kimlova LJ, Pyne C, Keshavjee K, Huy J, Beebakhee G, Bognar AL
Arch Biochem Biophys 1991 Jan;284(1):9-16
PubMed ID: 1989505