Pseudomonas aeruginosa PAO1, PA3470

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3470
Name
Replicon chromosome
Genomic location 3882980 - 3883438 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
CommentPyocyanin content was increased in a PA3470 mutant [PMID:32419387]
Comment PA3470 mutant is susceptible to killing by H2O2 [PMID:32419387]

Cross-References

RefSeq NP_252160.1
GI 15598666
Affymetrix PA3470_i_at
DNASU PaCD00007524
Entrez 879924
GenBank AAG06858.1
INSDC AAG06858.1
NCBI Locus Tag PA3470
protein_id(GenBank) gb|AAG06858.1|AE004768_3|gnl|PseudoCAP|PA3470
TIGR NTL03PA03470
UniParc UPI00000C5A2C
UniProtKB Acc Q9HYD6
UniProtKB ID Q9HYD6_PSEAE
UniRef100 UniRef100_W0YVS8
UniRef50 UniRef50_Q02QV9
UniRef90 UniRef90_A6V1V6

Product

Feature Type CDS
Coding Frame 1
Product Name
NUDIX hydrolase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -4.86
Kyte-Doolittle Hydrophobicity Value -0.318
Molecular Weight (kDa) 16.7
Isoelectric Point (pI) 5.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 106 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002171 (523 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3470
Search term: NUDIX hydrolase

Human Homologs

References

Individual Nudix hydrolases affect diverse features of Pseudomonas aeruginosa.
Drabinska J, Ziecina M, Modzelan M, Jagura-Burdzy G, Kraszewska E
Microbiologyopen 2020 Aug;9(8):e1052
PubMed ID: 32419387