Pseudomonas aeruginosa PAO1, PA3507

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3507
Name
Replicon chromosome
Genomic location 3923759 - 3924556 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252197.1
GI 15598703
Affymetrix PA3507_at
DNASU PaCD00007543
Entrez 879158
GenBank AAG06895.1
INSDC AAG06895.1
NCBI Locus Tag PA3507
protein_id(GenBank) gb|AAG06895.1|AE004771_4|gnl|PseudoCAP|PA3507
TIGR NTL03PA03507
UniParc UPI00000C5A43
UniProtKB Acc Q9HYA2
UniProtKB ID Q9HYA2_PSEAE
UniRef100 UniRef100_S0J5S5
UniRef50 UniRef50_F8GRS4
UniRef90 UniRef90_S0J5S5

Product

Feature Type CDS
Coding Frame 1
Product Name
probable short-chain dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) 1.81
Kyte-Doolittle Hydrophobicity Value 0.090
Molecular Weight (kDa) 28.5
Isoelectric Point (pI) 7.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3LF1 OXIDOREDUCTASE 01/15/10 Apo structure of The Short Chain Oxidoreductase Q9HYA2 from Pseudomonas aeruginosa PAO1 Containing an Atypical Catalytic Center Pseudomonas aeruginosa 2.315 X-RAY DIFFRACTION 100.0
3LF2 OXIDOREDUCTASE 01/15/10 NADPH Bound Structure of the Short Chain Oxidoreductase Q9HYA2 from Pseudomonas aeruginosa PAO1 Containing an Atypical Catalytic Center Pseudomonas aeruginosa 2.3 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 652 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG008377 (134 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3507

Human Homologs

Ensembl 110, assembly GRCh38.p14
peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:18281]
E-value: 5.2e-24
Percent Identity: 31.2

References

The short-chain oxidoreductase Q9HYA2 from Pseudomonas aeruginosa PAO1 contains an atypical catalytic center.
Huether R, Mao Q, Duax WL, Umland TC
Protein Sci 2010 May;19(5):1097-103
PubMed ID: 20340135