Pseudomonas aeruginosa PAO1, PA3754

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3754
Name
Synonym: yeaB
Replicon chromosome
Genomic location 4205296 - 4205907 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentPyocyanin content was increased in a PA3754 mutant [PMID:32419387]
Comment PA3754 mutant is susceptible to killing by H2O2 [PMID:32419387]

Cross-References

RefSeq NP_252443.1
GI 15598949
Affymetrix PA3754_at
DNASU PaCD00007636
Entrez 880431
GenBank AAG07141.1
INSDC AAG07141.1
NCBI Locus Tag PA3754
protein_id(GenBank) gb|AAG07141.1|AE004794_6|gnl|PseudoCAP|PA3754
TIGR NTL03PA03754
UniParc UPI00000C5AF4
UniProtKB Acc Q9HXP1
UniProtKB ID Q9HXP1_PSEAE
UniRef100 UniRef100_W0YYE6
UniRef50 UniRef50_Q4KHR7
UniRef90 UniRef90_A6V113

Product

Feature Type CDS
Coding Frame 1
Product Name
NUDIX hydrolase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.83
Kyte-Doolittle Hydrophobicity Value -0.141
Molecular Weight (kDa) 22.9
Isoelectric Point (pI) 4.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 359 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001928 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3754
Search term: NUDIX hydrolase

Human Homologs

References

Individual Nudix hydrolases affect diverse features of Pseudomonas aeruginosa.
Drabinska J, Ziecina M, Modzelan M, Jagura-Burdzy G, Kraszewska E
Microbiologyopen 2020 Aug;9(8):e1052
PubMed ID: 32419387