Pseudomonas aeruginosa PAO1, PA3812 (iscA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3812
Name
iscA
Replicon chromosome
Genomic location 4270148 - 4270471 (- strand)

Cross-References

RefSeq NP_252501.1
GI 15599007
Affymetrix PA3812_iscA_at
DNASU PaCD00007660
Entrez 879916
GenBank AAG07199.1
INSDC AAG07199.1
NCBI Locus Tag PA3812
protein_id(GenBank) gb|AAG07199.1|AE004799_5|gnl|PseudoCAP|PA3812
TIGR NTL03PA03812
UniParc UPI00000C5B21
UniProtKB Acc Q9HXJ0
UniProtKB ID Q9HXJ0_PSEAE
UniRef100 UniRef100_W0YWX9
UniRef50 UniRef50_X4JE89
UniRef90 UniRef90_Q1IEJ0

Product

Feature Type CDS
Coding Frame 1
Product Name
probable iron-binding protein IscA
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.62
Kyte-Doolittle Hydrophobicity Value -0.135
Molecular Weight (kDa) 11.6
Isoelectric Point (pI) 4.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 443 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001854 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3812
Search term: iscA

Human Homologs

Ensembl 110, assembly GRCh38.p14
iron-sulfur cluster assembly 1 [Source:HGNC Symbol;Acc:HGNC:28660]
E-value: 1.8e-20
Percent Identity: 40.6

References

Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii.
Zheng L, Cash VL, Flint DH, Dean DR
J Biol Chem 1998 May 22;273(21):13264-72
PubMed ID: 9582371