Pseudomonas aeruginosa PAO1, PA3903 (prfC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3903
Name
prfC
Replicon chromosome
Genomic location 4371969 - 4373552 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252592.1
GI 15599098
Affymetrix PA3903_prfC_at
Entrez 878928
GenBank AAG07290.1
INSDC AAG07290.1
NCBI Locus Tag PA3903
protein_id(GenBank) gb|AAG07290.1|AE004807_9|gnl|PseudoCAP|PA3903
TIGR NTL03PA03903
UniParc UPI0000133788
UniProtKB Acc Q9HXB0
UniProtKB ID RF3_PSEAE
UniRef100 UniRef100_B7VBK5
UniRef50 UniRef50_Q9KU64
UniRef90 UniRef90_A6V0K2

Product

Feature Type CDS
Coding Frame 1
Product Name
peptide chain release factor 3
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -12.84
Kyte-Doolittle Hydrophobicity Value -0.367
Molecular Weight (kDa) 59.9
Isoelectric Point (pI) 5.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001772 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3903
Search term: prfC

Human Homologs

Ensembl 110, assembly GRCh38.p14
G elongation factor mitochondrial 1 [Source:HGNC Symbol;Acc:HGNC:13780]
E-value: 1.5e-46
Percent Identity: 29.1
Ensembl 110, assembly GRCh38.p14
G elongation factor mitochondrial 1 [Source:HGNC Symbol;Acc:HGNC:13780]
E-value: 1.5e-46
Percent Identity: 29.1

References

Identification of the prfC gene, which encodes peptide-chain-release factor 3 of Escherichia coli.
Mikuni O, Ito K, Moffat J, Matsumura K, McCaughan K, Nobukuni T, Tate W, Nakamura Y
Proc Natl Acad Sci U S A 1994 Jun 21;91(13):5798-802
PubMed ID: 8016068