Pseudomonas aeruginosa PAO1, PA3910 (eddA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3910
Name
eddA
Replicon chromosome
Genomic location 4379687 - 4381249 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
Comment

Cross-References

RefSeq NP_252599.1
GI 15599105
Affymetrix PA3910_at
Entrez 878963
GenBank AAG07297.1
INSDC AAG07297.1
NCBI Locus Tag PA3910
protein_id(GenBank) gb|AAG07297.1|AE004808_7|gnl|PseudoCAP|PA3910
TIGR NTL03PA03910
UniParc UPI00000C5B70
UniProtKB Acc Q9HXA3
UniProtKB ID Q9HXA3_PSEAE
UniRef100 UniRef100_Q9HXA3
UniRef50 UniRef50_L8F5G2
UniRef90 UniRef90_Q9HXA3

Product

Feature Type CDS
Coding Frame 1
Product Name
Extracelullar DNA degradation protein, EddA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.38
Kyte-Doolittle Hydrophobicity Value -0.520
Molecular Weight (kDa) 58.7
Isoelectric Point (pI) 8.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Extracellular Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 159 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001766 (433 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3910
Search term: eddA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Secreted Phosphatase and Deoxyribonuclease Are Required by Pseudomonas aeruginosa To Defend against Neutrophil Extracellular Traps.
Wilton M, Halverson TWR, Charron-Mazenod L, Parkins MD, Lewenza S
Infect Immun 2018 Sep;86(9)
PubMed ID: 29967090