Pseudomonas aeruginosa PAO1, PA4063

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4063
Name
Replicon chromosome
Genomic location 4541272 - 4541862 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252752.1
GI 15599258
Affymetrix PA4063_at
Entrez 878821
GenBank AAG07450.1
INSDC AAG07450.1
NCBI Locus Tag PA4063
protein_id(GenBank) gb|AAG07450.1|AE004822_10|gnl|PseudoCAP|PA4063
TIGR NTL03PA04063
UniParc UPI00000C5BE9
UniProtKB Acc Q9HWW5
UniProtKB ID Q9HWW5_PSEAE
UniRef100 UniRef100_Q9HWW5
UniRef50 UniRef50_Q9HWW5
UniRef90 UniRef90_Q9HWW5

Product

Feature Type CDS
Coding Frame 1
Product Name
hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -6.49
Kyte-Doolittle Hydrophobicity Value -0.334
Molecular Weight (kDa) 21.2
Isoelectric Point (pI) 6.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7BGO METAL BINDING PROTEIN 01/08/21 The crystal structure of gene product PA4063 from Pseudomonas aeruginosa in complex with Zn (space group P65) Pseudomonas aeruginosa 3.301 X-RAY DIFFRACTION 100.0
7AHW METAL BINDING PROTEIN 09/25/20 The crystal structure of gene product PA4063 from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 1.952 X-RAY DIFFRACTION 100.0
7AMX METAL BINDING PROTEIN 10/09/20 The crystal structure of gene product PA4063 from Pseudomonas aeruginosa in complex with zinc Pseudomonas aeruginosa 2.85 X-RAY DIFFRACTION 100.0
7ALY METAL BINDING PROTEIN 10/07/20 The crystal structure of gene product PA4063 from Pseudomonas aeruginosa in complex with Au(I) for phasing Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.7 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 39 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001622 (529 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4063

Human Homologs

References

Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994