Pseudomonas aeruginosa PAO1, PA4153

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4153
Name
Replicon chromosome
Genomic location 4646720 - 4647811 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1

Cross-References

RefSeq NP_252842.1
GI 15599348
Affymetrix PA4153_at
DNASU PaCD00007805
Entrez 880134
GenBank AAG07540.1
INSDC AAG07540.1
NCBI Locus Tag PA4153
protein_id(GenBank) gb|AAG07540.1|AE004831_12|gnl|PseudoCAP|PA4153
TIGR NTL03PA04153
UniParc UPI00000C5C3E
UniProtKB Acc Q9HWM8
UniProtKB ID Q9HWM8_PSEAE
UniRef100 UniRef100_Q9HWM8
UniRef50 UniRef50_G8QCK0
UniRef90 UniRef90_Q02SW9

Product

Feature Type CDS
Coding Frame 1
Product Name
2,3-butanediol dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -9.71
Kyte-Doolittle Hydrophobicity Value 0.255
Molecular Weight (kDa) 38.2
Isoelectric Point (pI) 5.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 564 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001548 (736 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4153

Human Homologs

Ensembl 110, assembly GRCh38.p14
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Source:HGNC Symbol;Acc:HGNC:256]
E-value: 2.6e-18
Percent Identity: 24.5
Ensembl 110, assembly GRCh38.p14
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Source:HGNC Symbol;Acc:HGNC:256]
E-value: 2.6e-18
Percent Identity: 24.5
Ensembl 110, assembly GRCh38.p14
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Source:HGNC Symbol;Acc:HGNC:256]
E-value: 2.6e-18
Percent Identity: 24.5

References

Molecular characterization of the Pseudomonas putida 2,3-butanediol catabolic pathway.
Huang M, Oppermann FB, Steinbüchel A
FEMS Microbiol Lett 1994 Dec 1;124(2):141-50
PubMed ID: 7813883