Pseudomonas aeruginosa PAO1, PA4223

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4223
Name
Synonym: pchH
Replicon chromosome
Genomic location 4728614 - 4730326 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_252913.1
GI 15599419
Affymetrix PA4223_at
Entrez 880074
GenBank AAG07611.1
INSDC AAG07611.1
NCBI Locus Tag PA4223
protein_id(GenBank) gb|AAG07611.1|AE004839_4|gnl|PseudoCAP|PA4223
TIGR NTL03PA04224
UniParc UPI00000C6EB7
UniProtKB Acc Q9HWG6
UniProtKB ID Q9HWG6_PSEAE
UniRef100 UniRef100_G3XCL8
UniRef50 UniRef50_Q399S2
UniRef90 UniRef90_G3XCL8

Product

Feature Type CDS
Coding Frame 1
Product Name
probable ATP-binding component of ABC transporter
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -2.31
Kyte-Doolittle Hydrophobicity Value 0.362
Molecular Weight (kDa) 61.3
Isoelectric Point (pI) 6.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0095
Category Pyochelin
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001485 (685 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4223

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 6 (Langereis blood group) [Source:HGNC Symbol;Acc:HGNC:47]
E-value: 1.6e-41
Percent Identity: 41.3
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 6 (Langereis blood group) [Source:HGNC Symbol;Acc:HGNC:47]
E-value: 1.6e-41
Percent Identity: 41.3

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Essential PchG-dependent reduction in pyochelin biosynthesis of Pseudomonas aeruginosa.
Reimmann C, Patel HM, Serino L, Barone M, Walsh CT, Haas D
J Bacteriol 2001 Feb;183(3):813-20
PubMed ID: 11208777
YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis.
Fetherston JD, Bertolino VJ, Perry RD
Mol Microbiol 1999 Apr;32(2):289-99
PubMed ID: 10231486