Pseudomonas aeruginosa PAO1, PA4227 (pchR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4227
Name
pchR
Replicon chromosome
Genomic location 4741305 - 4742195 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_252917.1
GI 15599423
Affymetrix PA4227_pchR_at
DNASU PaCD00007834
Entrez 880049
GenBank AAG07615.1
INSDC AAG07615.1
NCBI Locus Tag PA4227
protein_id(GenBank) gb|AAG07615.1|AE004840_1|gnl|PseudoCAP|PA4227
TIGR NTL03PA04228
UniParc UPI00001313EA
UniProtKB Acc P40883
UniProtKB ID PCHR_PSEAE
UniRef100 UniRef100_P40883
UniRef50 UniRef50_P40883
UniRef90 UniRef90_P40883

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator PchR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.99
Kyte-Doolittle Hydrophobicity Value -0.161
Molecular Weight (kDa) 32.3
Isoelectric Point (pI) 7.39

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0095
Category Pyochelin
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 328 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001482 (1152 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4227
Search term: pchR

Human Homologs

References

PchR, a regulator of ferripyochelin receptor gene (fptA) expression in Pseudomonas aeruginosa, functions both as an activator and as a repressor.
Heinrichs DE, Poole K
J Bacteriol 1996 May;178(9):2586-92
PubMed ID: 8626326
Cloning and sequence analysis of a gene (pchR) encoding an AraC family activator of pyochelin and ferripyochelin receptor synthesis in Pseudomonas aeruginosa.
Heinrichs DE, Poole K
J Bacteriol 1993 Sep;175(18):5882-9
PubMed ID: 8397186