Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4397
|
Name |
panE
Synonym: abpA |
Replicon | chromosome |
Genomic location | 4927036 - 4927947 (+ strand) |
Transposon Mutants | 3 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_253087.1 |
GI | 15599593 |
Affymetrix | PA4397_panE_at |
Entrez | 881354 |
GenBank | AAG07785.1 |
INSDC | AAG07785.1 |
NCBI Locus Tag | PA4397 |
protein_id(GenBank) | gb|AAG07785.1|AE004855_7|gnl|PseudoCAP|PA4397 |
TIGR | NTL03PA04398 |
UniParc | UPI00001312D6 |
UniProtKB Acc | Q9HW09 |
UniProtKB ID | PANE_PSEAE |
UniRef100 | UniRef100_Q9HW09 |
UniRef50 | UniRef50_Q9HW09 |
UniRef90 | UniRef90_Q9HW09 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
ketopantoate reductase
|
Synonyms |
thiamin biosynthesis protein alternative pyrimidine biosynthesis protein |
Evidence for Translation | |
Charge (pH 7) | 7.22 |
Kyte-Doolittle Hydrophobicity Value | -0.218 |
Molecular Weight (kDa) | 33.1 |
Isoelectric Point (pI) | 8.82 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
5ZIX | OXIDOREDUCTASE | 03/17/18 | Crystal structure of Ketopantoate reductase from Pseudomonas aeruginosa bound to NADP+ | Pseudomonas aeruginosa PAO1 | 2.57 | X-RAY DIFFRACTION | 100.0 |
5ZIK | OXIDOREDUCTASE | 03/16/18 | Crystal structure of Ketopantoate reductase from Pseudomonas aeruginosa | Pseudomonas aeruginosa PAO1 | 2.45 | X-RAY DIFFRACTION | 100.0 |
6K1R | OXIDOREDUCTASE | 05/12/19 | Crystal structure of Ketopantoate reductase from Pseudomonas aeruginosa in complex with NAD+ and ketopantoate | Pseudomonas aeruginosa PAO1 | 2.55 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 288 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003987 (534 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4397
Search term: panE
Search term: ketopantoate reductase
|
apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium.
Downs DM, Petersen L
J Bacteriol 1994 Aug;176(16):4858-64
PubMed ID: 7519593
|
ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway.
Frodyma ME, Downs D
J Biol Chem 1998 Mar 6;273(10):5572-6
PubMed ID: 9488683
|
The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium.
Frodyma ME, Downs D
J Bacteriol 1998 Sep;180(17):4757-9
PubMed ID: 9721324
|