Pseudomonas aeruginosa PAO1, PA4434

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4434
Name
Replicon chromosome
Genomic location 4966190 - 4967227 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253124.1
GI 15599630
Affymetrix PA4434_at
DNASU PaCD00007923
Entrez 880942
GenBank AAG07822.1
INSDC AAG07822.1
NCBI Locus Tag PA4434
protein_id(GenBank) gb|AAG07822.1|AE004857_13|gnl|PseudoCAP|PA4434
TIGR NTL03PA04435
UniParc UPI00000C5D0D
UniProtKB Acc Q9HVY1
UniProtKB ID Q9HVY1_PSEAE
UniRef100 UniRef100_W1MQ46
UniRef50 UniRef50_A0A084A210
UniRef90 UniRef90_W1MQ46

Product

Feature Type CDS
Coding Frame 1
Product Name
probable oxidoreductase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -5.40
Kyte-Doolittle Hydrophobicity Value -0.370
Molecular Weight (kDa) 38.6
Isoelectric Point (pI) 5.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 523 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004024 (529 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4434

Human Homologs

Ensembl 110, assembly GRCh38.p14
potassium voltage-gated channel subfamily A regulatory beta subunit 2 [Source:HGNC Symbol;Acc:HGNC:6229]
E-value: 4.5e-28
Percent Identity: 27.6

References

Reversion of the tyrosine ochre strain Escherichia coli WU3610 under starvation conditions depends on a new gene tas.
Timms AR, Bridges BA
Genetics 1998 Apr;148(4):1627-35
PubMed ID: 9560382
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994