Pseudomonas aeruginosa PAO1, PA5110 (fbp)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5110
Name
fbp
Synonym: cfxF
Synonym: cbbF
Replicon chromosome
Genomic location 5752464 - 5753474 (- strand)

Cross-References

RefSeq NP_253797.1
GI 15600303
Affymetrix PA5110_fbp_at
Entrez 882240
GenBank AAG08495.1
INSDC AAG08495.1
NCBI Locus Tag PA5110
protein_id(GenBank) gb|AAG08495.1|AE004923_11|gnl|PseudoCAP|PA5110
TIGR NTL03PA05111
UniParc UPI00000C5F08
UniProtKB Acc Q9HU73
UniProtKB ID F16PA_PSEAE
UniRef100 UniRef100_B7V3K3
UniRef50 UniRef50_Q31FI6
UniRef90 UniRef90_B7V3K3

Product

Feature Type CDS
Coding Frame 1
Product Name
fructose-1,6-bisphosphatase
Product Name Confidence: Class 2
Synonyms fbpase
hexosediphosphatase
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.13
Kyte-Doolittle Hydrophobicity Value -0.274
Molecular Weight (kDa) 37.2
Isoelectric Point (pI) 5.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 306 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004705 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5110
Search term: fbp

Human Homologs

Ensembl 110, assembly GRCh38.p14
fructose-bisphosphatase 2 [Source:HGNC Symbol;Acc:HGNC:3607]
E-value: 1.0e-64
Percent Identity: 41.2

References

Fructose-bisphosphatase-deficient mutants of mucoid Pseudomonas aeruginosa.
Banerjee PC
Folia Microbiol (Praha) 1989;34(2):81-6
PubMed ID: 2546876
Sequence analysis of the chromosomal and plasmid genes encoding phosphoribulokinase from Alcaligenes eutrophus.
Kossmann J, Klintworth R, Bowien B
Gene 1989 Dec 21;85(1):247-52
PubMed ID: 2559876
Analysis of the cbbF genes from Alcaligenes eutrophus that encode fructose-1,6-/sedoheptulose-1,7-bisphosphatase.
Yoo JG, Bowien B
Curr Microbiol 1995 Jul;31(1):55-61
PubMed ID: 7767230
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994