Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA5259
|
Name |
hemD
|
Replicon | chromosome |
Genomic location | 5920742 - 5921497 (- strand) |
RefSeq | NP_253946.1 |
GI | 15600452 |
Affymetrix | PA5259_hemD_at |
DNASU | PaCD00008267 |
Entrez | 879724 |
GenBank | AAG08644.1 |
INSDC | AAG08644.1 |
NCBI Locus Tag | PA5259 |
protein_id(GenBank) | gb|AAG08644.1|AE004938_6|gnl|PseudoCAP|PA5259 |
TIGR | NTL03PA05260 |
UniParc | UPI000012C4A8 |
UniProtKB Acc | P48246 |
UniProtKB ID | HEM4_PSEAE |
UniRef100 | UniRef100_P48246 |
UniRef50 | UniRef50_P48246 |
UniRef90 | UniRef90_P48246 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
uroporphyrinogen-III synthetase
|
Synonyms |
hydroxymethylbilane hydrolyase (cyclizing) |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -6.64 |
Kyte-Doolittle Hydrophobicity Value | -0.053 |
Molecular Weight (kDa) | 27.2 |
Isoelectric Point (pI) | 4.76 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6TH8 | FLAVOPROTEIN | 11/19/19 | Reconstructing the Origins of the HemD-like fold | Thermus thermophilus | NOT | SOLUTION NMR | 94.7 |
4ES6 | LYASE | 04/22/12 | Crystal structure of HemD (PA5259) from Pseudomonas aeruginosa (PAO1) at 2.22 A resolution | Pseudomonas aeruginosa | 2.22 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 195 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004840 (518 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA5259
Search term: hemD
Search term: uroporphyrinogen-III synthetase
|
Molecular cloning and sequencing of the hemD gene of Escherichia coli K-12 and preliminary data on the Uro operon.
Sasarman A, Nepveu A, Echelard Y, Dymetryszyn J, Drolet M, Goyer C
J Bacteriol 1987 Sep;169(9):4257-62
PubMed ID: 3040684
|
The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR.
Mohr CD, Sonsteby SK, Deretic V
Mol Gen Genet 1994 Jan;242(2):177-84
PubMed ID: 8159168
|