Pseudomonas aeruginosa PAO1, PA0243 (pip)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0243
Name
pip
Replicon chromosome
Genomic location 275772 - 276440 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 19 transposon mutants in orthologs
CommentDeletion of pip causes decreased pyocyanin biosynthesis in P. aeruginosa (PMID:32707314)

Cross-References

RefSeq NP_248934.1
GI 15595440
Affymetrix PA0243_at
DNASU PaCD00006108
Entrez 881956
GenBank AAG03632.1
INSDC AAG03632.1
NCBI Locus Tag PA0243
protein_id(GenBank) gb|AAG03632.1|AE004462_5|gnl|PseudoCAP|PA0243
TIGR NTL03PA00244
UniParc UPI00000C4FBA
UniProtKB Acc Q9I6P5
UniProtKB ID Q9I6P5_PSEAE
UniRef100 UniRef100_W0YL16
UniRef50 UniRef50_Q4K5N1
UniRef90 UniRef90_W0YL16

Product

Feature Type CDS
Coding Frame 1
Product Name
Pip
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.89
Kyte-Doolittle Hydrophobicity Value -0.353
Molecular Weight (kDa) 25.3
Isoelectric Point (pI) 9.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 264 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000241 (6008 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0243
Search term: pip
Search term: Pip

Human Homologs

References

Pip serves as an intermediate in RpoS-modulated phz2 expression and pyocyanin production in Pseudomonas aeruginosa.
Chen L, Xu X, Fan C, Zhang R, Ji Y, Yu Z, Qu H, Feng Z, Chi X, Cheng S, Ge Y
Microb Pathog 2020 Oct;147:104409
PubMed ID: 32707314