Pseudomonas aeruginosa PAO1, PA1113

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1113
Name
Replicon chromosome
Genomic location 1205771 - 1207537 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentPA1113 as an ABC transporter used for drug influx, allowing the entry of carbenicillin into the cytoplasm (PMID:32933058)

Cross-References

RefSeq NP_249804.1
GI 15596310
Affymetrix PA1113_at
Entrez 882144
GenBank AAG04502.1
INSDC AAG04502.1
NCBI Locus Tag PA1113
protein_id(GenBank) gb|AAG04502.1|AE004541_7|gnl|PseudoCAP|PA1113
TIGR NTL03PA01114
UniParc UPI00000C5254
UniProtKB Acc Q9I4M2
UniProtKB ID Q9I4M2_PSEAE
UniRef100 UniRef100_Q9I4M2
UniRef50 UniRef50_D7HY21
UniRef90 UniRef90_Q76LI0

Product

Feature Type CDS
Coding Frame 1
Product Name
ABC transporter
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 11.66
Kyte-Doolittle Hydrophobicity Value 0.338
Molecular Weight (kDa) 64.0
Isoelectric Point (pI) 10.25

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001073 (497 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1113
Search term: ABC transporter

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 10 [Source:HGNC Symbol;Acc:HGNC:41]
E-value: 9.6e-79
Percent Identity: 37.0

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Identification of the PA1113 Gene Product as an ABC Transporter Involved in the Uptake of Carbenicillin in Pseudomonas aeruginosa PAO1.
Hulen C, Racine PJ, Chevalier S, Feuilloley M, Lomri NE
Antibiotics (Basel) 2020 Sep 11;9(9)
PubMed ID: 32933058