Pseudomonas aeruginosa PAO1, PA0262 (vgrG2b)

Annotation Updates

Date	Description	Acknowledgements
Oct 9, 2019	New product name confidence: Class 1. New comment: H2-T6SS evolved effector demonstrating antibacterial and anti-eukaryotic activity (trans-kingdom toxin) delivered into epithelial cells through the H2-T6SS machinery and VgrG2a (PA1511); The C-Terminal domain of VgrG2b interacts with the gamma-tubulin complex to promote a microtubule-dependant internalization of P. aeruginosa into non phagocytic cells (PMID:26037124); Required for Tle3 secretion, the C-Terminal domain of VgrG2b is antibacterial when delivered into the periplasm of prey bacteria (in the heterologous host E. coli) and its toxicity relies on an intact protease catalytic site (residus 932-941, PFAM04298);Tli3 neutralizes the antibacterial activity of VgrG2b (PMID:31231326). New PMIDs: 26037124, 31231326.	Sophie Bleves, Institute of Microbiology of the Mediterranean, France
Nov 24, 2014	New gene name: vgrG2b. New product name name: VgrG2b. New product name confidence: Class 2. New PubMed ID: 21325275.	Luke Allsopp and Alain Filloux, Imperial College.