Pseudomonas aeruginosa PAO1, PA0677 (hxcW)

Annotation Updates

Date	Description	Acknowledgements
May 12, 2006	New structure feature: Manually-identified prepilin peptidase substrate (type IV) export signal (MSGYAERATTRRRQAGFTLIE)	Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Jun 10, 2004	Annotation of gene previously described as probable type II secretion system protein (Class 3). New protein name: HxcW putative pseudopilin. New evidence reference (PubMed ID): 11985723. New homology added: 48% similar and 32% identical to XcpW protein [Pseudomonas alcaligenes] . New genomic context added: Ribosome binding site: AGGCGAA from -12 to -6 . New structure features added. The leader peptide extends between residues 1 to 16, and includes the invariant glycine after which cleavage by the prepilin peptidase takes place. The new N-terminal residue phenylalanine precedes twenty highly hydrophobic residues. New comments: Hxc proteins are involved in the secretion of alkaline phosphatase. hxc gene cluster is under phosphate regulation. general secretory pathway protein J family.	Raymond C. Lo and Fiona S.L. Brinkman, Simon Fraser University, Canada (based on literature review);
May 8, 2015	New gene name: hxcW. New product name: HxcW. New product name confidence: Class 1.	Rome Voulhoux, CNRS, Marseille, France