Pseudomonas aeruginosa PAO1, PA1272 (cobO)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Molecular Function | GO:0008817 | cob(I)yrinic acid a,c-diamide adenosyltransferase activity | Inferred from Sequence or Structural Similarity | ECO:0000250 sequence similarity evidence used in manual assertion |
1917862 | Reviewed by curator |
| Biological Process | GO:0009236 | cobalamin biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF015617
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0008817 | cob(I)yrinic acid a,c-diamide adenosyltransferase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF015617
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0005524 | ATP binding |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF015617
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| PseudoCyc | PWY-5509 | adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCAP | Porphyrin and chlorophyll metabolism |
ECO:0000037
not_recorded |
|||
| PseudoCyc | PWY-5508 | adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | P381-PWY | adenosylcobalamin biosynthesis II (late cobalt incorporation) | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae01100 | Metabolic pathways | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pae00860 | Porphyrin and chlorophyll metabolism | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCAP | Cobalamin biosynthesis |
ECO:0000037
not_recorded |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| PANTHER | PTHR46638 | CORRINOID ADENOSYLTRANSFERASE | IPR003724 | ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR | 5 | 203 | 4.7E-69 |
| MobiDBLite | mobidb-lite | consensus disorder prediction | - | - | 1 | 21 | - |
| Gene3D | G3DSA:3.40.50.300 | - | IPR027417 | P-loop containing nucleoside triphosphate hydrolase | 11 | 203 | 7.5E-67 |
| PIRSF | PIRSF015617 | Adenosyltransferase_CobA | IPR003724 | ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR | 6 | 203 | 3.5E-71 |
| Pfam | PF12557 | Cob(I)alamin adenosyltransferase N terminal | IPR025826 | Cob(I)alamin adenosyltransferase N-terminal domain | 1 | 26 | 7.4E-10 |
| Coils | Coil | Coil | - | - | 12 | 32 | - |
| CDD | cd00561 | CobA_ACA | IPR003724 | ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR | 33 | 203 | 1.0077E-88 |
| Pfam | PF02572 | ATP:corrinoid adenosyltransferase BtuR/CobO/CobP | IPR003724 | ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR | 33 | 203 | 2.0E-58 |
| NCBIfam | TIGR00708 | JCVI: cob(I)yrinic acid a,c-diamide adenosyltransferase | IPR003724 | ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR | 29 | 203 | 4.4E-68 |
| SUPERFAMILY | SSF52540 | P-loop containing nucleoside triphosphate hydrolases | IPR027417 | P-loop containing nucleoside triphosphate hydrolase | 12 | 203 | 1.53E-71 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.