Pseudomonas aeruginosa PAO1, PA1871 (lasA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006508 proteolysis
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 1597429 Reviewed by curator
Biological Process GO:0015628 protein secretion by the type II secretion system
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9642203 Reviewed by curator
Molecular Function GO:0004175 endopeptidase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9642203 Reviewed by curator
Cellular Component GO:0005615 extracellular space
IDA
Inferred from Direct Assay 		ECO:0001230
mass spectrometry evidence used in manual assertion		 25488299 Reviewed by curator
Biological Process GO:0043952 protein transport by the Sec complex
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9642203 Reviewed by curator
Biological Process GO:0006508 proteolysis
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00933
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004222 metalloendopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00933
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Secreted Factors (toxins, enzymes, alginate) Other PAO1 genes in this class
Translation, post-translational modification, degradation Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02024 Quorum sensing 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Xcp type II secretion system ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF01551 Peptidase family M23 IPR016047 Peptidase M23 286 367 2.7E-11
FunFam G3DSA:2.70.70.10:FF:000044 Protease LasA - - 237 418 4.2E-129
PANTHER PTHR21666 PEPTIDASE-RELATED - - 205 368 2.3E-10
Gene3D G3DSA:2.70.70.10 Glucose Permease (Domain IIA) IPR011055 Duplicated hybrid motif 237 418 2.4E-54
PRINTS PR00933 B-lytic metalloendopeptidase (M23) signature IPR000841 Peptidase M23A, B-lytic metalloendopeptidase 244 265 1.6E-57
PRINTS PR00933 B-lytic metalloendopeptidase (M23) signature IPR000841 Peptidase M23A, B-lytic metalloendopeptidase 266 284 1.6E-57
CDD cd12797 M23_peptidase - - 287 361 6.00773E-17
PRINTS PR00933 B-lytic metalloendopeptidase (M23) signature IPR000841 Peptidase M23A, B-lytic metalloendopeptidase 372 395 1.6E-57
SUPERFAMILY SSF51261 Duplicated hybrid motif IPR011055 Duplicated hybrid motif 226 365 2.3E-17
PRINTS PR00933 B-lytic metalloendopeptidase (M23) signature IPR000841 Peptidase M23A, B-lytic metalloendopeptidase 293 311 1.6E-57
PRINTS PR00933 B-lytic metalloendopeptidase (M23) signature IPR000841 Peptidase M23A, B-lytic metalloendopeptidase 345 365 1.6E-57

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.