Pseudomonas aeruginosa PAO1, PA2081 (kynB)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0008150	biological_process	IDA Inferred from Direct Assay	ECO:0000002 direct assay evidence
Molecular Function	GO:0004061	arylformamidase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	14592712	Reviewed by curator
Biological Process	GO:0019441	tryptophan catabolic process to kynurenine	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	17337571	Reviewed by curator
Biological Process	GO:0006520	cellular amino acid metabolic process	IDA Inferred from Direct Assay	ECO:0000002 direct assay evidence
Cellular Component	GO:0005575	cellular_component	IDA Inferred from Direct Assay	ECO:0000002 direct assay evidence
Molecular Function	GO:0004328	formamidase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01969	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0019441	tryptophan catabolic process to kynurenine	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:3.50.30.50	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004061	arylformamidase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:3.50.30.50	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	PWY-5651	L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCAP		anthranilate		ECO:0000037 not_recorded
PseudoCyc	TRYPTOPHAN-DEGRADATION-1	L-tryptophan degradation III (eukaryotic)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00380	Tryptophan metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00630	Glyoxylate and dicarboxylate metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		kynurenine pathway		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Gene3D	G3DSA:3.50.30.50	Putative cyclase	IPR037175	Kynurenine formamidase superfamily	1	213	1.4E-67
Hamap	MF_01969	Kynurenine formamidase [kynB].	IPR017484	Kynurenine formamidase, bacteria	5	209	45.107018
FunFam	G3DSA:3.50.30.50:FF:000001	Kynurenine formamidase	-	-	3	209	5.0E-89
PANTHER	PTHR31118	CYCLASE-LIKE PROTEIN 2	IPR007325	Kynurenine formamidase/cyclase-like	5	206	9.5E-25
SUPERFAMILY	SSF102198	Putative cyclase	IPR037175	Kynurenine formamidase superfamily	4	207	9.81E-60
NCBIfam	TIGR03035	JCVI: arylformamidase	IPR017484	Kynurenine formamidase, bacteria	5	209	3.7E-104
Pfam	PF04199	Putative cyclase	IPR007325	Kynurenine formamidase/cyclase-like	8	152	6.9E-18

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.