Pseudomonas aeruginosa PAO1, PA2524 (czcS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 10570969 Reviewed by curator
Biological Process GO:0000160 phosphorelay signal transduction system
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01386
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016772 transferase activity, transferring phosphorus-containing groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00512
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00512
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004673 protein histidine kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01386
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0016310 phosphorylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01386
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Two-component regulatory systems Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Two-component System ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Coils Coil Coil - - 286 306 -
CDD cd06225 HAMP - - 200 243 3.54937E-7
SUPERFAMILY SSF158472 HAMP domain-like - - 198 245 4.84E-7
SMART SM00304 HAMP_11 IPR003660 HAMP domain 195 248 1.5E-11
Pfam PF00512 His Kinase A (phospho-acceptor) domain IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 250 313 1.6E-7
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 Histidine kinase/HSP90-like ATPase 359 467 1.4E-23
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 413 423 9.5E-11
Coils Coil Coil - - 36 56 -
Pfam PF00672 HAMP domain IPR003660 HAMP domain 192 245 4.0E-12
Gene3D G3DSA:6.10.340.10 - - - 160 248 1.1E-11
NCBIfam TIGR01386 JCVI: heavy metal sensor histidine kinase IPR006290 Heavy metal sensor kinase 5 467 0.0
SUPERFAMILY SSF47384 Homodimeric domain of signal transducing histidine kinase IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily 232 314 1.26E-13
SUPERFAMILY SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase IPR036890 Histidine kinase/HSP90-like ATPase superfamily 305 467 4.58E-38
Gene3D G3DSA:1.10.287.130 - - - 249 314 1.6E-8
SMART SM00388 HisKA_10 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 249 315 2.4E-9
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 395 409 9.5E-11
Gene3D G3DSA:3.30.565.10 - IPR036890 Histidine kinase/HSP90-like ATPase superfamily 323 470 7.9E-37
PANTHER PTHR45436 SENSOR HISTIDINE KINASE YKOH - - 4 469 4.2E-70
SMART SM00387 HKATPase_4 IPR003594 Histidine kinase/HSP90-like ATPase 358 470 2.0E-35
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 430 448 9.5E-11
CDD cd00075 HATPase - - 363 466 4.25131E-37
CDD cd00082 HisKA IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 248 309 2.74571E-9
FunFam G3DSA:3.30.565.10:FF:000006 Sensor histidine kinase WalK - - 320 470 6.4E-35

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.