Pseudomonas aeruginosa PAO1, PA2903 (cobJ)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0009236	cobalamin biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	8226690	Reviewed by curator
Biological Process	GO:0051188	obsolete cofactor biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0008168	methyltransferase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:SSF53790	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009236	cobalamin biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:cd11646	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCyc	P381-PWY	adenosylcobalamin biosynthesis II (late cobalt incorporation)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00860	Porphyrin and chlorophyll metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Cobalamin biosynthesis		ECO:0000037 not_recorded
PseudoCyc	PWY-7376	cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
MetaCyc		cob(II)yrinate <i>a,c</i>-diamide biosynthesis I (early cobalt insertion)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
SUPERFAMILY	SSF159672	CbiG N-terminal domain-like	IPR038029	GbiG N-terminal domain superfamily	7	212	1.18E-41
Gene3D	G3DSA:3.40.1010.10	-	IPR014777	Tetrapyrrole methylase, subdomain 1	302	422	9.8E-27
PANTHER	PTHR47036	COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED	-	-	300	558	1.1E-96
SUPERFAMILY	SSF53790	Tetrapyrrole methylase	IPR035996	Tetrapyrrole methylase superfamily	307	556	2.49E-53
NCBIfam	TIGR01466	JCVI: precorrin-3B C(17)-methyltransferase	IPR006363	Precorrin-3B C17-methyltransferase domain	310	556	1.4E-84
Gene3D	G3DSA:3.40.50.11220	-	-	-	2	126	2.6E-20
CDD	cd11646	Precorrin_3B_C17_MT	IPR006363	Precorrin-3B C17-methyltransferase domain	310	556	9.05901E-114
Pfam	PF00590	Tetrapyrrole (Corrin/Porphyrin) Methylases	IPR000878	Tetrapyrrole methylase	309	520	4.5E-34
Gene3D	G3DSA:3.30.950.10	-	IPR014776	Tetrapyrrole methylase, subdomain 2	423	557	9.9E-52
Pfam	PF11760	Cobalamin synthesis G N-terminal	IPR021744	Cobalamin synthesis G, N-terminal	52	130	7.3E-23

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.