Pseudomonas aeruginosa PAO1, PA2948 (cobM)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0051188	obsolete cofactor biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0008168	methyltransferase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00590	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0046026	precorrin-4 C11-methyltransferase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:cd11641	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009236	cobalamin biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:cd11641	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00860	Porphyrin and chlorophyll metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	PWY-7376	cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	P381-PWY	adenosylcobalamin biosynthesis II (late cobalt incorporation)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCAP		Cobalamin biosynthesis		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Gene3D	G3DSA:3.30.950.10	-	IPR014776	Tetrapyrrole methylase, subdomain 2	111	231	1.7E-35
Pfam	PF00590	Tetrapyrrole (Corrin/Porphyrin) Methylases	IPR000878	Tetrapyrrole methylase	2	206	5.4E-48
Coils	Coil	Coil	-	-	51	71	-
CDD	cd11641	Precorrin-4_C11-MT	IPR006362	Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase	6	228	2.89573E-126
Gene3D	G3DSA:3.40.1010.10	-	IPR014777	Tetrapyrrole methylase, subdomain 1	1	109	2.3E-31
PANTHER	PTHR45790	SIROHEME SYNTHASE-RELATED	-	-	2	232	8.0E-61
SUPERFAMILY	SSF53790	Tetrapyrrole methylase	IPR035996	Tetrapyrrole methylase superfamily	2	229	1.27E-68
NCBIfam	TIGR01465	JCVI: precorrin-4 C(11)-methyltransferase	IPR006362	Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase	3	247	1.5E-97

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.