Pseudomonas aeruginosa PAO1, PA2981 (lpxK)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Cellular Component	GO:0009276	Gram-negative-bacterium-type cell wall	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Biological Process	GO:0009103	lipopolysaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0005524	ATP binding	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00682	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0009029	tetraacyldisaccharide 4'-kinase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00682	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009245	lipid A biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00682	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCAP		Lipopolysaccharide biosynthesis		ECO:0000037 not_recorded
PseudoCyc	KDO-NAGLIPASYN-PWY	superpathway of (Kdo)<SUB>2</SUB>-lipid A biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00540	Lipopolysaccharide biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	NAGLIPASYN-PWY	lipid IV<sub>A</sub> biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PEP-LIPA-SYN-PWY	peptidoglycan and lipid A precursor biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	KDO-PEP-LIPASYN-PWY	KDO<SUB>2</SUB>-lipid A and peptidoglycan biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Hamap	MF_00409	Tetraacyldisaccharide 4'-kinase [lpxK].	IPR003758	Tetraacyldisaccharide 4'-kinase	3	331	39.240265
NCBIfam	TIGR00682	JCVI: tetraacyldisaccharide 4'-kinase	IPR003758	Tetraacyldisaccharide 4'-kinase	27	313	9.2E-79
SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	IPR027417	P-loop containing nucleoside triphosphate hydrolase	53	191	7.53E-14
PANTHER	PTHR42724	TETRAACYLDISACCHARIDE 4'-KINASE	IPR003758	Tetraacyldisaccharide 4'-kinase	15	330	2.2E-73
Pfam	PF02606	Tetraacyldisaccharide-1-P 4'-kinase	IPR003758	Tetraacyldisaccharide 4'-kinase	19	326	3.3E-106

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.