Pseudomonas aeruginosa PAO1, PA3014 (faoA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0050695 benzoylformate decarboxylase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019605 butyrate metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006568 tryptophan metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006574 valine catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019541 propionate metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006554 lysine catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019482 beta-alanine metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006631 fatty acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006633 fatty acid biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006552 leucine catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006550 isoleucine catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0044255 cellular lipid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0008692 3-hydroxybutyryl-CoA epimerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01621
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0070403 NAD+ binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02737
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00725
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006631 fatty acid metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00725
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00725
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01621
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0036125 fatty acid beta-oxidation multienzyme complex
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01621
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009062 fatty acid catabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01621
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004165 dodecenoyl-CoA delta-isomerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01621
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004300 enoyl-CoA hydratase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01621
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class
Fatty acid and phospholipid metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Fatty acid metabolism ECO:0000037
not_recorded
PseudoCAP Lysine degradation ECO:0000037
not_recorded
KEGG pae00903 Limonene and pinene degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00930 Caprolactam degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00410 beta-Alanine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00281 Geraniol degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00650 Butanoate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01212 Fatty acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Propanoate metabolism ECO:0000037
not_recorded
KEGG pae00362 Benzoate degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Valine, leucine and isoleucine degradation ECO:0000037
not_recorded
PseudoCAP Beta-Alanine metabolism ECO:0000037
not_recorded
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00280 Valine, leucine and isoleucine degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Fatty acid biosynthesis (path 2) ECO:0000037
not_recorded
PseudoCAP Tryptophan metabolism ECO:0000037
not_recorded
PseudoCAP Butanoate metabolism ECO:0000037
not_recorded
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00640 Propanoate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00380 Tryptophan metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01040 Biosynthesis of unsaturated fatty acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00310 Lysine degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00071 Fatty acid degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal 497 592 3.3E-25
CDD cd06558 crotonase-like - - 16 204 6.04648E-57
NCBIfam TIGR02437 JCVI: fatty acid oxidation complex subunit alpha FadB IPR012799 Fatty oxidation complex, alpha subunit FadB 1 714 0.0
Pfam PF00378 Enoyl-CoA hydratase/isomerase IPR001753 Enoyl-CoA hydratase/isomerase 17 212 9.0E-40
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 314 496 1.76E-56
Gene3D G3DSA:3.40.50.720 - - - 314 499 2.4E-66
PANTHER PTHR43612 TRIFUNCTIONAL ENZYME SUBUNIT ALPHA - - 3 714 0.0
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 496 616 3.57E-29
Gene3D G3DSA:3.90.226.10 - - - 1 313 8.0E-121
SUPERFAMILY SSF52096 ClpP/crotonase IPR029045 ClpP/crotonase-like domain superfamily 2 308 8.83E-70
Gene3D G3DSA:1.10.1040.50 - - - 500 704 6.8E-71
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 622 714 6.29E-24
Hamap MF_01621 Fatty acid oxidation complex subunit alpha [fadB]. IPR012799 Fatty oxidation complex, alpha subunit FadB 1 715 52.228764
FunFam G3DSA:3.40.50.720:FF:000009 Fatty oxidation complex, alpha subunit - - 314 499 5.6E-73
FunFam G3DSA:1.10.1040.50:FF:000001 Fatty acid oxidation complex subunit alpha - - 500 714 2.3E-118
FunFam G3DSA:3.90.226.10:FF:000018 Fatty acid oxidation complex subunit alpha - - 1 313 0.0
Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding 317 495 8.5E-61

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.