Pseudomonas aeruginosa PAO1, PA3345 (hptB)

Annotation Updates

Date	Description	Acknowledgements
Aug 25, 2011	New product name: Histidine phosphotransfer protein HptB. New gene name: hptB. New product name confidence: Class 1. New comment : Using in vitro phosphorylation and bacterial two hybrid analysis, Lin et al. and Hsu et al. subsequently showed that HptB can be phosphorylated by four hybrid sensors, PA1611, PA1976, PA2824 and RetS, and that HptB can transfer a phosphate onto the adjacent response regulator PA3346.. New comment : using genetic, bacterial two hybrid and biochemical analyses, Bordi et al. showed that HptB actually has a negative effect on the activity of the PA3346 response regulator, the function of which is to activate the anti-?-factor PA3347.. New comment : . It was further shown that the HptB signalling pathway intersects the GacA signalling pathway that inversely controls the expression the pel genes involved in biofilm formation and the type III secretion system.. New function class: Two-component regulatory systems. New GO Accession: GO:0009927(IDA). New PubMed reference: 11121759. New PubMed reference: 16182517. New PubMed reference: 18256026. New PubMed reference: 20398205.	Allain Filloux, Imperial College London
Mar 5, 2012	New function class: Motility & Attachment. New PubMed reference: 22128156. New genomic context: PA3347, PA3346, and hptB are organized as an operon (PMID:18256026).	Literature review. Geoffrey L. Winsor (Brinkman Lab). Simon Fraser University, Canada