Pseudomonas aeruginosa PAO1, PA3438 (folE1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006729 tetrahydrobiopterin biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 1985963 Reviewed by curator
Biological Process GO:0051188 obsolete cofactor biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11109
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003934 GTP cyclohydrolase I activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11109
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00790 Folate biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Folate biosynthesis ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.30.1130.10 - IPR043133 GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase 53 185 5.3E-64
NCBIfam TIGR00063 JCVI: GTP cyclohydrolase I FolE IPR001474 GTP cyclohydrolase I 6 183 4.8E-77
FunFam G3DSA:1.10.286.10:FF:000009 GTP cyclohydrolase 1 - - 1 50 2.4E-30
FunFam G3DSA:3.30.1130.10:FF:000001 GTP cyclohydrolase 1 - - 53 184 5.2E-61
Pfam PF01227 GTP cyclohydrolase I IPR020602 GTP cyclohydrolase I domain 6 182 1.9E-75
Hamap MF_00223 GTP cyclohydrolase 1 [folE]. IPR001474 GTP cyclohydrolase I 1 183 39.246246
SUPERFAMILY SSF55620 Tetrahydrobiopterin biosynthesis enzymes-like - - 5 183 8.89E-79
CDD cd00642 GTP_cyclohydro1 - - 3 184 2.88187E-97
Gene3D G3DSA:1.10.286.10 - IPR043134 GTP cyclohydrolase I, N-terminal domain 1 50 1.8E-19
PANTHER PTHR11109 GTP CYCLOHYDROLASE I IPR001474 GTP cyclohydrolase I 3 183 3.9E-85

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.