Pseudomonas aeruginosa PAO1, PA3439 (folX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006729 tetrahydrobiopterin biosynthetic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 19897652 Reviewed by curator
Biological Process GO:0051188 obsolete cofactor biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0004150 dihydroneopterin aldolase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02152
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006760 folic acid-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02152
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Folate biosynthesis ECO:0000037
not_recorded
PseudoCAP tetrahydromonapterin synthesis ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.30.1130.10:FF:000005 D-erythro-7,8-dihydroneopterin triphosphate epimerase - - 4 123 1.1E-62
NCBIfam TIGR00526 JCVI: FolB domain IPR006157 Dihydroneopterin aldolase/epimerase domain 8 119 5.1E-31
PANTHER PTHR42844 DIHYDRONEOPTERIN ALDOLASE 1-RELATED IPR006156 Dihydroneopterin aldolase 6 120 1.5E-22
SUPERFAMILY SSF55620 Tetrahydrobiopterin biosynthesis enzymes-like - - 7 120 2.48E-30
CDD cd00534 DHNA_DHNTPE IPR006157 Dihydroneopterin aldolase/epimerase domain 8 119 1.14958E-30
SMART SM00905 FolB_2 IPR006157 Dihydroneopterin aldolase/epimerase domain 11 121 1.1E-32
Pfam PF02152 Dihydroneopterin aldolase IPR006157 Dihydroneopterin aldolase/epimerase domain 11 119 2.5E-25
Gene3D G3DSA:3.30.1130.10 - IPR043133 GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase 6 122 3.8E-33

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.