Pseudomonas aeruginosa PAO1, PA3471

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0004470	malic enzyme activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PR00072	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0051287	NAD binding	ISM Inferred from Sequence Model Term mapped from: InterPro:SM00919	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PR00072	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Central intermediary metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00620	Pyruvate metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01200	Carbon metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae02020	Two-component system	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
PRINTS	PR00072	Malic enzyme signature	IPR001891	Malic oxidoreductase	407	423	2.9E-72
SMART	SM00919	Malic_M_2	IPR012302	Malic enzyme, NAD-binding	269	530	6.2E-129
PRINTS	PR00072	Malic enzyme signature	IPR001891	Malic oxidoreductase	145	174	2.9E-72
PRINTS	PR00072	Malic enzyme signature	IPR001891	Malic oxidoreductase	85	109	2.9E-72
PRINTS	PR00072	Malic enzyme signature	IPR001891	Malic oxidoreductase	181	203	2.9E-72
PRINTS	PR00072	Malic enzyme signature	IPR001891	Malic oxidoreductase	240	258	2.9E-72
Gene3D	G3DSA:3.40.50.10380	-	IPR037062	Malic enzyme, N-terminal domain superfamily	15	266	3.7E-110
PANTHER	PTHR23406	MALIC ENZYME-RELATED	-	-	10	559	0.0
SUPERFAMILY	SSF53223	Aminoacid dehydrogenase-like, N-terminal domain	IPR046346	Aminoacid dehydrogenase-like, N-terminal domain superfamily	5	268	7.19E-107
Pfam	PF00390	Malic enzyme, N-terminal domain	IPR012301	Malic enzyme, N-terminal domain	79	259	3.8E-77
Pfam	PF03949	Malic enzyme, NAD binding domain	IPR012302	Malic enzyme, NAD-binding	269	529	2.9E-105
Gene3D	G3DSA:3.40.50.720	-	-	-	267	564	2.4E-105
PRINTS	PR00072	Malic enzyme signature	IPR001891	Malic oxidoreductase	296	312	2.9E-72
SMART	SM01274	malic_2	IPR012301	Malic enzyme, N-terminal domain	79	259	9.1E-105
PRINTS	PR00072	Malic enzyme signature	IPR001891	Malic oxidoreductase	265	281	2.9E-72
FunFam	G3DSA:3.40.50.10380:FF:000001	NAD-dependent malic enzyme	-	-	14	266	0.0
FunFam	G3DSA:3.40.50.720:FF:000055	NAD-dependent malic enzyme	-	-	267	563	0.0
PIRSF	PIRSF000106	ME	IPR001891	Malic oxidoreductase	1	562	0.0
Hamap	MF_01619	NAD-dependent malic enzyme [maeA].	IPR023667	NAD-dependent malic enzyme, proteobacteria	2	564	70.344315
SUPERFAMILY	SSF51735	NAD(P)-binding Rossmann-fold domains	IPR036291	NAD(P)-binding domain superfamily	269	561	1.0E-92

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.