Pseudomonas aeruginosa PAO1, PA3495 (nth)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006259 DNA metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0004519 endonuclease activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2669955 Reviewed by curator
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF10576
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00633
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006284 base-excision repair
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00056
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF48150
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01083
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006281 DNA repair
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF48150
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

DNA replication, recombination, modification and repair Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae03410 Base excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SMART SM00478 endo3end IPR003265 HhH-GPD domain 38 185 1.8E-59
PIRSF PIRSF001435 Nth - - 1 212 1.9E-52
NCBIfam TIGR01083 JCVI: endonuclease III IPR005759 Endonuclease III 5 194 8.8E-86
FunFam G3DSA:1.10.340.30:FF:000001 Endonuclease III - - 21 132 1.8E-43
Gene3D G3DSA:1.10.340.30 Hypothetical protein; domain 2 - - 21 132 8.2E-83
Gene3D G3DSA:1.10.1670.10 - IPR023170 Helix-hairpin-helix, base-excision DNA repair, C-terminal 12 205 8.2E-83
PANTHER PTHR10359 A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III - - 2 210 5.0E-80
SUPERFAMILY SSF48150 DNA-glycosylase IPR011257 DNA glycosylase 3 208 1.88E-73
SMART SM00525 ccc3 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif 186 206 5.2E-5
Pfam PF00633 Helix-hairpin-helix motif IPR000445 Helix-hairpin-helix motif 100 127 7.0E-10
Pfam PF10576 Iron-sulfur binding domain of endonuclease III IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif 187 203 4.7E-4
Hamap MF_00942 Endonuclease III [nth]. IPR005759 Endonuclease III 1 209 37.767784
FunFam G3DSA:1.10.1670.10:FF:000001 Endonuclease III - - 127 205 1.3E-33
CDD cd00056 ENDO3c IPR003265 HhH-GPD domain 30 183 1.02354E-54
Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein IPR003265 HhH-GPD domain 34 168 1.8E-20

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.