Pseudomonas aeruginosa PAO1, PA3540 (algD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006970 response to osmotic stress
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 2496102 Reviewed by curator
Molecular Function GO:0047919 GDP-mannose 6-dehydrogenase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 7521247 Reviewed by curator
Biological Process GO:0036460 cellular response to cell envelope stress
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 17020580 Reviewed by curator
Molecular Function GO:0047919 GDP-mannose 6-dehydrogenase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 2470755 Reviewed by curator
Biological Process GO:0009628 response to abiotic stimulus
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 24496793 Reviewed by curator
Biological Process GO:0042121 alginic acid biosynthetic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 7521247 Reviewed by curator
Biological Process GO:0050896 response to stimulus
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0042121 alginic acid biosynthetic process
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 7521247 Reviewed by curator
Biological Process GO:0044010 single-species biofilm formation
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 7521247 Reviewed by curator
Biological Process GO:0009607 response to biotic stimulus
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 18455339 Reviewed by curator
Molecular Function GO:0051287 NAD binding
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 12705829 Reviewed by curator
Cellular Component GO:0009276 Gram-negative-bacterium-type cell wall

Biological Process GO:0042121 alginic acid biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF500135
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0047919 GDP-mannose 6-dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF500135
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00984
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR03026
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class
Secreted Factors (toxins, enzymes, alginate) Other PAO1 genes in this class
Adaptation, Protection Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Alginate biosynthesis ECO:0000037
not_recorded
PseudoCyc PWY-6082 alginate biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Fructose and mannose metabolism ECO:0000037
not_recorded
KEGG pae02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00520 Amino sugar and nucleotide sugar metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00051 Fructose and mannose metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation 205 298 2.1E-28
PANTHER PTHR43750 UDP-GLUCOSE 6-DEHYDROGENASE TUAD - - 1 404 3.1E-114
Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal 1 190 6.0E-63
Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal 318 405 2.6E-12
PIRSF PIRSF000124 UDPglc_GDPman_dh IPR017476 UDP-glucose/GDP-mannose dehydrogenase 1 436 0.0
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 1 195 2.91E-51
Gene3D G3DSA:3.40.50.720 - - - 1 202 5.9E-80
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 204 300 7.48E-28
FunFam G3DSA:3.40.50.720:FF:000573 GDP-mannose 6-dehydrogenase - - 1 202 0.0
Gene3D G3DSA:1.20.5.170 - - - 203 234 6.4E-20
FunFam G3DSA:3.40.50.720:FF:000664 GDP-mannose 6-dehydrogenase - - 235 436 0.0
NCBIfam TIGR03026 JCVI: nucleotide sugar dehydrogenase IPR017476 UDP-glucose/GDP-mannose dehydrogenase 1 410 1.1E-130
SMART SM00984 UDPG_MGDP_dh_C_a_2_a IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal 317 425 2.2E-19
SUPERFAMILY SSF52413 UDP-glucose/GDP-mannose dehydrogenase C-terminal domain IPR036220 UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily 305 434 2.62E-25
PIRSF PIRSF500135 GDPman_DH IPR028358 GDP-mannose 6-dehydrogenase 1 436 0.0
Gene3D G3DSA:3.40.50.720 - - - 235 436 3.3E-58

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.