Pseudomonas aeruginosa PAO1, PA3574 (nalD)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0000976	transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	17028276	Reviewed by curator
Biological Process	GO:0034763	negative regulation of transmembrane transport	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	17028276	Reviewed by curator
Molecular Function	GO:0003677	DNA binding	IDA Inferred from Direct Assay	ECO:0000096 electrophoretic mobility shift assay evidence	17028276	Reviewed by curator
Biological Process	GO:0051051	negative regulation of transport	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	15855496	Reviewed by curator
Biological Process	GO:0045892	negative regulation of transcription, DNA-templated	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	17028276	Reviewed by curator
Biological Process	GO:0032410	negative regulation of transporter activity	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	17028276	Reviewed by curator
Molecular Function	GO:0003677	DNA binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00440	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Antibiotic resistance and susceptibility Other PAO1 genes in this class Transcriptional regulators Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01501	beta-Lactam resistance	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Pfam	PF00440	Bacterial regulatory proteins, tetR family	IPR001647	DNA-binding HTH domain, TetR-type	15	61	7.9E-18
FunFam	G3DSA:1.10.357.10:FF:000003	HTH-type transcriptional regulator AcrR	-	-	1	212	1.4E-83
Pfam	PF08361	MAATS-type transcriptional repressor, C-terminal region	IPR013572	Transcription regulator MAATS, C-terminal	83	198	3.0E-13
PANTHER	PTHR30055	HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR	-	-	2	207	4.4E-26
FunFam	G3DSA:1.10.10.60:FF:000141	TetR family transcriptional regulator	-	-	8	59	3.8E-15
Gene3D	G3DSA:1.10.357.10	Tetracycline Repressor, domain 2	-	-	1	212	5.6E-98
SUPERFAMILY	SSF46689	Homeodomain-like	IPR009057	Homeobox-like domain superfamily	1	65	7.98E-19
SUPERFAMILY	SSF48498	Tetracyclin repressor-like, C-terminal domain	IPR036271	Tetracyclin repressor-like, C-terminal domain superfamily	83	202	7.56E-12
PRINTS	PR00455	TetR bacterial regulatory protein HTH signature	IPR001647	DNA-binding HTH domain, TetR-type	15	28	6.8E-12
PRINTS	PR00455	TetR bacterial regulatory protein HTH signature	IPR001647	DNA-binding HTH domain, TetR-type	36	59	6.8E-12

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.