Pseudomonas aeruginosa PAO1, PA3643 (lpxB)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0009103 | lipopolysaccharide biosynthetic process | Inferred from Sequence or Structural Similarity | ECO:0000250 sequence similarity evidence used in manual assertion |
3531165 | Reviewed by curator |
| Cellular Component | GO:0009276 | Gram-negative-bacterium-type cell wall | Inferred from Sequence or Structural Similarity | ECO:0000044 sequence similarity evidence |
||
| Molecular Function | GO:0016757 | transferase activity, transferring glycosyl groups |
Inferred from Sequence or Structural Similarity
Term mapped from: CAZy:GT19
|
ECO:0000250 sequence similarity evidence used in manual assertion |
18838391 | Reviewed by curator |
| Molecular Function | GO:0008915 | lipid-A-disaccharide synthase activity |
Inferred from Sequence Model
Term mapped from: InterPro:MF_00392
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0009245 | lipid A biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:MF_00392
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| PseudoCyc | PEP-LIPA-SYN-PWY | peptidoglycan and lipid A precursor biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae00540 | Lipopolysaccharide biosynthesis | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCyc | KDO-NAGLIPASYN-PWY | superpathway of (Kdo)<SUB>2</SUB>-lipid A biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | KDO-PEP-LIPASYN-PWY | KDO<SUB>2</SUB>-lipid A and peptidoglycan biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae01100 | Metabolic pathways | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCAP | Lipopolysaccharide biosynthesis |
ECO:0000037
not_recorded |
|||
| PseudoCyc | NAGLIPASYN-PWY | lipid IV<sub>A</sub> biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| Hamap | MF_00392 | Lipid-A-disaccharide synthase [lpxB]. | IPR003835 | Glycosyl transferase, family 19 | 4 | 376 | 44.081444 |
| Gene3D | G3DSA:3.40.50.2000 | Glycogen Phosphorylase B; | - | - | 170 | 371 | 1.8E-6 |
| NCBIfam | TIGR00215 | JCVI: lipid-A-disaccharide synthase | IPR003835 | Glycosyl transferase, family 19 | 6 | 374 | 7.3E-127 |
| FunFam | G3DSA:3.40.50.2000:FF:000245 | Lipid-A-disaccharide synthase | - | - | 170 | 371 | 0.0 |
| SUPERFAMILY | SSF53756 | UDP-Glycosyltransferase/glycogen phosphorylase | - | - | 6 | 375 | 1.54E-38 |
| Pfam | PF02684 | Lipid-A-disaccharide synthetase | IPR003835 | Glycosyl transferase, family 19 | 7 | 360 | 3.3E-121 |
| PANTHER | PTHR30372 | LIPID-A-DISACCHARIDE SYNTHASE | IPR003835 | Glycosyl transferase, family 19 | 5 | 377 | 7.0E-111 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.