Pseudomonas aeruginosa PAO1, PA3644 (lpxA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0009103 | lipopolysaccharide biosynthetic process | Inferred from Direct Assay | ECO:0000314 direct assay evidence used in manual assertion |
1904818 | Reviewed by curator |
| Cellular Component | GO:0009276 | Gram-negative-bacterium-type cell wall | Inferred from Sequence or Structural Similarity | ECO:0000044 sequence similarity evidence |
||
| Molecular Function | GO:0008780 | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43480
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0008610 | lipid biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43480
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG | pae01100 | Metabolic pathways | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCyc | NAGLIPASYN-PWY | lipid IV<sub>A</sub> biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCAP | Lipopolysaccharide biosynthesis |
ECO:0000037
not_recorded |
|||
| KEGG | pae01503 | Cationic antimicrobial peptide (CAMP) resistance | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCyc | PEP-LIPA-SYN-PWY | peptidoglycan and lipid A precursor biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | KDO-NAGLIPASYN-PWY | superpathway of (Kdo)<SUB>2</SUB>-lipid A biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae00540 | Lipopolysaccharide biosynthesis | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCyc | KDO-PEP-LIPASYN-PWY | KDO<SUB>2</SUB>-lipid A and peptidoglycan biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| Pfam | PF13720 | Udp N-acetylglucosamine O-acyltransferase; Domain 2 | IPR029098 | UDP N-acetylglucosamine O-acyltransferase, C-terminal | 176 | 256 | 9.2E-27 |
| CDD | cd03351 | LbH_UDP-GlcNAc_AT | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 4 | 256 | 0.0 |
| PIRSF | PIRSF000456 | UDP-GlcNAc_acltr | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 1 | 258 | 1.7E-99 |
| PANTHER | PTHR43480 | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 2 | 257 | 8.4E-86 |
| Gene3D | G3DSA:2.160.10.10 | Hexapeptide repeat proteins | - | - | 1 | 191 | 2.0E-57 |
| NCBIfam | TIGR01852 | JCVI: acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 4 | 256 | 6.5E-95 |
| Pfam | PF00132 | Bacterial transferase hexapeptide (six repeats) | IPR001451 | Hexapeptide repeat | 105 | 137 | 1.6E-8 |
| FunFam | G3DSA:2.160.10.10:FF:000003 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | - | - | 1 | 192 | 4.8E-101 |
| Gene3D | G3DSA:1.20.1180.10 | - | IPR037157 | UDP-N-acetylglucosamine O-acyltransferase, C-terminal domain superfamily | 193 | 258 | 4.0E-25 |
| FunFam | G3DSA:1.20.1180.10:FF:000001 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | - | - | 193 | 258 | 9.5E-36 |
| SUPERFAMILY | SSF51161 | Trimeric LpxA-like enzymes | IPR011004 | Trimeric LpxA-like superfamily | 3 | 258 | 3.83E-77 |
| Hamap | MF_00387 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase [lpxA]. | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 1 | 258 | 45.217983 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.