Pseudomonas aeruginosa PAO1, PA3792 (leuA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009097 isoleucine biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0009909 regulation of flower development
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0003852 2-isopropylmalate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08502
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009098 leucine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08502
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00682
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Valine, leucine and isoleucine biosynthesis ECO:0000037
not_recorded
PseudoCyc LEUSYN-PWY L-leucine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc BRANCHED-CHAIN-AA-SYN-PWY superpathway of branched amino acid biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01210 2-Oxocarboxylic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF08502 LeuA allosteric (dimerisation) domain IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 458 583 9.0E-29
PANTHER PTHR46911 - - - 38 590 0.0
Pfam PF00682 HMGL-like IPR000891 Pyruvate carboxyltransferase 69 349 7.8E-79
FunFam G3DSA:3.20.20.70:FF:000045 2-isopropylmalate synthase - - 47 412 0.0
Hamap MF_00572 2-isopropylmalate synthase [leuA]. IPR005668 2-isopropylmalate synthase 44 585 54.378784
SUPERFAMILY SSF51569 Aldolase - - 58 366 1.5E-98
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 48 412 0.0
CDD cd07942 DRE_TIM_LeuA IPR039371 LeuA, N-terminal catalytic TIM barrel domain 69 351 0.0
NCBIfam TIGR00970 JCVI: 2-isopropylmalate synthase IPR005668 2-isopropylmalate synthase 43 584 0.0
SUPERFAMILY SSF110921 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain IPR036230 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily 479 583 2.22E-33
SUPERFAMILY SSF89000 post-HMGL domain-like - - 424 473 1.37E-13
FunFam G3DSA:3.30.160.270:FF:000006 2-isopropylmalate synthase - - 413 583 2.2E-73
Gene3D G3DSA:3.30.160.270 - IPR036230 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily 413 583 6.4E-56
SMART SM00917 LeuA_dimer_2 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 458 584 7.7E-31

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.