Pseudomonas aeruginosa PAO1, PA3946 (rocS1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 15659157 Reviewed by curator
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF47384
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016772 transferase activity, transferring phosphorus-containing groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0000160 phosphorelay signal transduction system
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00448
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0016310 phosphorylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF47384
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Two-component regulatory systems Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Two-component System ECO:0000037
not_recorded
KEGG pae02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00512 His Kinase A (phospho-acceptor) domain IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 709 775 3.0E-14
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 1057 1182 5.23E-18
Gene3D G3DSA:3.40.50.2300 - - - 952 1076 5.3E-35
CDD cd00082 HisKA IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 707 771 1.20802E-13
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 Histidine kinase/HSP90-like ATPase 823 935 1.4E-24
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 921 934 1.7E-11
CDD cd00088 HPT IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1119 1178 3.3009E-6
Gene3D G3DSA:3.40.190.10 - - - 384 479 8.3E-59
Gene3D G3DSA:3.40.190.10 - - - 141 234 1.4E-46
CDD cd13705 PBP2_BvgS_D1 - - 54 272 1.89068E-67
Gene3D G3DSA:3.40.190.10 - - - 289 516 8.3E-59
SMART SM00091 pas_2 IPR000014 PAS domain 574 642 0.001
SUPERFAMILY SSF47384 Homodimeric domain of signal transducing histidine kinase IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily 692 776 1.43E-17
FunFam G3DSA:3.30.565.10:FF:000010 Sensor histidine kinase RcsC - - 774 939 4.5E-45
SMART SM00448 REC_2 IPR001789 Signal transduction response regulator, receiver domain 958 1074 2.9E-31
PANTHER PTHR45339 HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J - - 684 936 2.9E-119
SUPERFAMILY SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase IPR036890 Histidine kinase/HSP90-like ATPase superfamily 765 935 6.68E-40
CDD cd17546 REC_hyHK_CKI1_RcsC-like - - 960 1074 3.18441E-44
SMART SM00062 AABind_6 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF 56 275 9.7E-18
SUPERFAMILY SSF53850 Periplasmic binding protein-like II - - 292 519 3.72E-37
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 881 891 1.7E-11
CDD cd00130 PAS IPR000014 PAS domain 583 686 2.61419E-7
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 863 877 1.7E-11
Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF 299 516 1.4E-29
Gene3D G3DSA:3.30.450.20 PAS domain - - 560 698 1.1E-17
Gene3D G3DSA:1.10.287.130 - - - 699 776 7.5E-21
Gene3D G3DSA:3.30.565.10 - IPR036890 Histidine kinase/HSP90-like ATPase superfamily 777 940 1.0E-43
Pfam PF01627 Hpt domain IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1121 1178 1.0E-8
CDD cd16922 HATPase_EvgS-ArcB-TorS-like - - 827 935 1.62714E-47
SMART SM00387 HKATPase_4 IPR003594 Histidine kinase/HSP90-like ATPase 822 937 1.1E-31
CDD cd13707 PBP2_BvgS_D2 - - 296 517 4.07977E-86
SUPERFAMILY SSF55785 PYP-like sensor domain (PAS domain) IPR035965 PAS domain superfamily 561 687 9.77E-18
SMART SM00388 HisKA_10 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 709 775 8.3E-19
Pfam PF08448 PAS fold IPR013656 PAS fold-4 583 690 8.9E-13
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 897 915 1.7E-11
Gene3D G3DSA:1.20.120.160 HPT domain IPR036641 HPT domain superfamily 1100 1205 1.3E-12
SUPERFAMILY SSF52172 CheY-like IPR011006 CheY-like superfamily 956 1076 1.57E-33
Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF 64 273 1.7E-25
Gene3D G3DSA:3.40.190.10 - - - 46 271 1.4E-46
Coils Coil Coil - - 686 709 -
SUPERFAMILY SSF53850 Periplasmic binding protein-like II - - 48 274 2.88E-32
Pfam PF00072 Response regulator receiver domain IPR001789 Signal transduction response regulator, receiver domain 960 1074 3.3E-25
SMART SM00062 AABind_6 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF 298 520 1.6E-24
NCBIfam TIGR00229 JCVI: PAS domain S-box protein IPR000014 PAS domain 577 692 5.7E-12

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.