Pseudomonas aeruginosa PAO1, PA4020 (mpl)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Cellular Component	GO:0009276	Gram-negative-bacterium-type cell wall	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Biological Process	GO:0071236	cellular response to antibiotic	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	24041903	Reviewed by curator
Biological Process	GO:0009058	biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01225	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0005524	ATP binding	ISM Inferred from Sequence Model Term mapped from: InterPro:SSF53623	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009252	peptidoglycan biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_02020	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0016881	acid-amino acid ligase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01225	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0071555	cell wall organization	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_02020	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class Antibiotic resistance and susceptibility Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCyc	PEP-LIPA-SYN-PWY	peptidoglycan and lipid A precursor biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	KDO-PEP-LIPASYN-PWY	KDO<SUB>2</SUB>-lipid A and peptidoglycan biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PEPTIDOGLYCANSYN-PWY	peptidoglycan biosynthesis I (meso-diaminopimelate containing)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PWY-6387	UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-DAP-containing)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
NCBIfam	TIGR01081	JCVI: UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase	IPR005757	Murein peptide ligase	2	449	0.0
Hamap	MF_02020	UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase [mpl].	IPR005757	Murein peptide ligase	1	450	60.764839
Gene3D	G3DSA:3.90.190.20	-	IPR036615	Mur ligase, C-terminal domain superfamily	314	451	3.6E-37
FunFam	G3DSA:3.40.50.720:FF:000161	UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase	-	-	1	90	2.6E-55
Gene3D	G3DSA:3.40.50.720	-	-	-	1	90	2.3E-34
SUPERFAMILY	SSF51984	MurCD N-terminal domain	-	-	1	90	1.57E-23
SUPERFAMILY	SSF53244	MurD-like peptide ligases, peptide-binding domain	IPR036615	Mur ligase, C-terminal domain superfamily	311	448	5.49E-34
Gene3D	G3DSA:3.40.1190.10	-	IPR036565	Mur-like, catalytic domain superfamily	91	313	1.1E-70
Pfam	PF01225	Mur ligase family, catalytic domain	IPR000713	Mur ligase, N-terminal catalytic domain	2	100	7.3E-22
Pfam	PF08245	Mur ligase middle domain	IPR013221	Mur ligase, central	108	291	3.5E-21
SUPERFAMILY	SSF53623	MurD-like peptide ligases, catalytic domain	IPR036565	Mur-like, catalytic domain superfamily	94	308	8.63E-53
Pfam	PF02875	Mur ligase family, glutamate ligase domain	IPR004101	Mur ligase, C-terminal	311	360	1.3E-8
PANTHER	PTHR43445	UDP-N-ACETYLMURAMATE--L-ALANINE LIGASE-RELATED	-	-	2	450	6.1E-111

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.