Pseudomonas aeruginosa PAO1, PA4201 (ddlA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008716 D-alanine-D-alanine ligase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 1554356 Reviewed by curator
Biological Process GO:0009252 peptidoglycan biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 1554356 Reviewed by curator
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008716 D-alanine-D-alanine ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF07478
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01502 Vancomycin resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PEPTIDOGLYCANSYN-PWY peptidoglycan biosynthesis I (meso-diaminopimelate containing) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc KDO-PEP-LIPASYN-PWY KDO<SUB>2</SUB>-lipid A and peptidoglycan biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00473 D-Alanine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-DAP-containing) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PEP-LIPA-SYN-PWY peptidoglycan and lipid A precursor biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00550 Peptidoglycan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.30.470.20 - - - 123 330 9.4E-74
SUPERFAMILY SSF52440 PreATP-grasp domain IPR016185 Pre-ATP-grasp domain superfamily 5 132 2.49E-26
Gene3D G3DSA:3.40.50.20 - - - 3 122 5.6E-25
Hamap MF_00047 D-alanine--D-alanine ligase [ddl]. IPR005905 D-alanine--D-alanine ligase 6 335 35.517426
PIRSF PIRSF039102 Ddl/VanB IPR005905 D-alanine--D-alanine ligase 3 343 1.7E-98
Pfam PF07478 D-ala D-ala ligase C-terminus IPR011095 D-alanine--D-alanine ligase, C-terminal 147 330 1.4E-51
PANTHER PTHR23132 D-ALANINE--D-ALANINE LIGASE - - 4 344 2.9E-71
NCBIfam TIGR01205 JCVI: D-alanine--D-alanine ligase IPR005905 D-alanine--D-alanine ligase 7 331 1.5E-87
Pfam PF01820 D-ala D-ala ligase N-terminus IPR011127 D-alanine--D-alanine ligase, N-terminal domain 7 123 5.7E-23
SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like - - 133 334 3.71E-54
Gene3D G3DSA:3.30.1490.20 - IPR013815 ATP-grasp fold, subdomain 1 148 211 9.4E-74

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.