Pseudomonas aeruginosa PAO1, PA4375 (mexW)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0042910 xenobiotic transmembrane transporter activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 12951344 Reviewed by curator
Biological Process GO:0006811 ion transport
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 12951344 Reviewed by curator
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0022857 transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055085 transmembrane transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Transport of small molecules Other PAO1 genes in this class
Membrane proteins Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01501 beta-Lactam resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 137 323 6.28E-24
Gene3D G3DSA:3.30.2090.10 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 701 789 0.0
Pfam PF00873 AcrB/AcrD/AcrF family IPR001036 Acriflavin resistance protein 6 1002 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 462 485 2.1E-75
SUPERFAMILY SSF82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 183 264 3.53E-16
SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain - - 808 1003 4.19E-44
Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain - - 9 494 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 329 352 2.1E-75
Gene3D G3DSA:3.30.2090.10 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 179 271 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 384 408 2.1E-75
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 356 377 2.1E-75
Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain - - 495 999 0.0
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 553 650 4.45E-23
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 650 832 1.88E-15
Gene3D G3DSA:3.30.70.1430 Multidrug efflux transporter AcrB pore domain - - 40 797 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 38 56 2.1E-75
SUPERFAMILY SSF82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 699 781 7.06E-17
Gene3D G3DSA:3.30.70.1430 Multidrug efflux transporter AcrB pore domain - - 558 650 0.0
Gene3D G3DSA:3.30.70.1320 Multidrug efflux transporter AcrB pore domain like - - 134 324 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 10 34 2.1E-75
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 437 460 2.1E-75
PANTHER PTHR32063 - IPR001036 Acriflavin resistance protein 1 1004 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 603 617 2.1E-75
SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain - - 290 490 3.4E-53
FunFam G3DSA:1.20.1640.10:FF:000001 Efflux pump membrane transporter - - 313 501 6.2E-71
Gene3D G3DSA:3.30.70.1440 Multidrug efflux transporter AcrB pore domain - - 651 846 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 540 557 2.1E-75
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 42 132 4.45E-20

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.