Pseudomonas aeruginosa PAO1, PA4696 (ilvI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009082 branched-chain amino acid biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 9581571 Reviewed by curator
Cellular Component GO:0005948 acetolactate synthase complex
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 9581571 Reviewed by curator
Molecular Function GO:0003984 acetolactate synthase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 9581571 Reviewed by curator
Molecular Function GO:0050660 flavin adenine dinucleotide binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00118
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009082 branched-chain amino acid biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00118
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003984 acetolactate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00118
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02775
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000287 magnesium ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00118
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0030976 thiamine pyrophosphate binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd02015
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00650 Butanoate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP C5-Branched dibasic acid metabolism ECO:0000037
not_recorded
PseudoCAP Pantothenate and CoA biosynthesis ECO:0000037
not_recorded
PseudoCyc BRANCHED-CHAIN-AA-SYN-PWY superpathway of branched amino acid biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00660 C5-Branched dibasic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Valine, leucine and isoleucine biosynthesis ECO:0000037
not_recorded
PseudoCyc ILEUSYN-PWY L-isoleucine biosynthesis I (from threonine) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01210 2-Oxocarboxylic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Butanoate metabolism ECO:0000037
not_recorded
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00770 Pantothenate and CoA biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 3 179 9.09E-66
SUPERFAMILY SSF52467 DHS-like NAD/FAD-binding domain IPR029035 DHS-like NAD/FAD-binding domain superfamily 189 360 4.36E-62
Gene3D G3DSA:3.40.50.1220 - - - 196 363 3.6E-121
Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain 5 166 1.0E-58
Gene3D G3DSA:3.40.50.970 - - - 365 544 3.6E-121
FunFam G3DSA:3.40.50.1220:FF:000008 Acetolactate synthase - - 190 362 4.2E-58
FunFam G3DSA:3.40.50.970:FF:000007 Acetolactate synthase - - 1 183 1.4E-75
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 374 567 5.31E-65
PANTHER PTHR18968 THIAMINE PYROPHOSPHATE ENZYMES IPR045229 Thiamine pyrophosphate enzyme 5 558 0.0
Gene3D G3DSA:3.40.50.970 - - - 2 186 1.6E-65
CDD cd02015 TPP_AHAS IPR039368 Acetolactate synthase large subunit, TPP binding domain 374 556 1.1198E-104
FunFam G3DSA:3.40.50.970:FF:000016 Acetolactate synthase - - 366 555 1.7E-73
Pfam PF00205 Thiamine pyrophosphate enzyme, central domain IPR012000 Thiamine pyrophosphate enzyme, central domain 196 330 1.0E-43
CDD cd07035 TPP_PYR_POX_like - - 8 163 2.44227E-77
NCBIfam TIGR00118 JCVI: biosynthetic-type acetolactate synthase large subunit IPR012846 Acetolactate synthase, large subunit, biosynthetic 4 569 0.0
Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain IPR011766 Thiamine pyrophosphate enzyme, TPP-binding 396 545 7.5E-49

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.