Pseudomonas aeruginosa PAO1, PA4729 (panB)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0051188	obsolete cofactor biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0000104	succinate dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Biological Process	GO:0015937	coenzyme A biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0003864	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF000388	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:SSF51621	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0015940	pantothenate biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF000388	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCAP		Pantothenate and CoA biosynthesis		ECO:0000037 not_recorded
PseudoCyc	PANTO-PWY	phosphopantothenate biosynthesis I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		One carbon pool by folate		ECO:0000037 not_recorded
PseudoCyc	PANTOSYN-PWY	pantothenate and coenzyme A biosynthesis I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		phosphopantothenate biosynthesis III (archaebacteria)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	pae00770	Pantothenate and CoA biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
CDD	cd06557	KPHMT-like	IPR003700	Ketopantoate hydroxymethyltransferase	6	258	0.0
Hamap	MF_00156	3-methyl-2-oxobutanoate hydroxymethyltransferase [panB].	IPR003700	Ketopantoate hydroxymethyltransferase	4	264	41.19352
NCBIfam	TIGR00222	JCVI: 3-methyl-2-oxobutanoate hydroxymethyltransferase	IPR003700	Ketopantoate hydroxymethyltransferase	4	264	4.6E-99
PANTHER	PTHR20881	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE	IPR003700	Ketopantoate hydroxymethyltransferase	2	264	3.6E-93
Pfam	PF02548	Ketopantoate hydroxymethyltransferase	IPR003700	Ketopantoate hydroxymethyltransferase	4	259	6.7E-105
Gene3D	G3DSA:3.20.20.60	-	IPR040442	Pyruvate kinase-like domain superfamily	1	264	4.4E-113
PIRSF	PIRSF000388	PanB	IPR003700	Ketopantoate hydroxymethyltransferase	2	266	5.3E-97
SUPERFAMILY	SSF51621	Phosphoenolpyruvate/pyruvate domain	IPR015813	Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily	4	264	1.99E-101
FunFam	G3DSA:3.20.20.60:FF:000003	3-methyl-2-oxobutanoate hydroxymethyltransferase	-	-	1	266	1.1E-111

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.