Pseudomonas aeruginosa PAO1, PA4750 (folP)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Cellular Component	GO:0005737	cytoplasm	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	1657875	Reviewed by curator
Molecular Function	GO:0004156	dihydropteroate synthase activity	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	1657875	Reviewed by curator
Molecular Function	GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	1657875	Reviewed by curator
Molecular Function	GO:0004156	dihydropteroate synthase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	1657875	Reviewed by curator
Biological Process	GO:0046656	folic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	1522070	Reviewed by curator
Biological Process	GO:0042558	pteridine-containing compound metabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00809	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009396	folic acid-containing compound biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:cd00739	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0044237	cellular metabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:3.20.20.20	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004156	dihydropteroate synthase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:cd00739	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	ALL-CHORISMATE-PWY	superpathway of chorismate metabolism	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00790	Folate biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Folate biosynthesis		ECO:0000037 not_recorded
PseudoCyc	PWY-6612	superpathway of tetrahydrofolate biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
MetaCyc		tetrahydrofolate biosynthesis	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
PseudoCyc	PWY-6614	tetrahydrofolate biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
SUPERFAMILY	SSF51717	Dihydropteroate synthetase-like	IPR011005	Dihydropteroate synthase-like	11	279	3.01E-104
CDD	cd00739	DHPS	IPR006390	Dihydropteroate synthase domain	22	275	1.63926E-122
Gene3D	G3DSA:3.20.20.20	-	IPR011005	Dihydropteroate synthase-like	8	283	2.8E-115
NCBIfam	TIGR01496	JCVI: dihydropteroate synthase	IPR006390	Dihydropteroate synthase domain	24	278	6.9E-100
FunFam	G3DSA:3.20.20.20:FF:000004	Dihydropteroate synthase	-	-	8	283	7.5E-127
PANTHER	PTHR20941	FOLATE SYNTHESIS PROTEINS	IPR045031	Dihydropteroate synthase	19	280	3.5E-105
Pfam	PF00809	Pterin binding enzyme	IPR000489	Pterin-binding domain	25	264	5.3E-85

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.