Pseudomonas aeruginosa PAO1, PA4977 (aruI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02775
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000287 magnesium ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0030976 thiamine pyrophosphate binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02776
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-5742 L-arginine degradation IX (arginine:pyruvate transaminase pathway) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc BRANCHED-CHAIN-AA-SYN-PWY superpathway of branched amino acid biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc ILEUSYN-PWY L-isoleucine biosynthesis I (from threonine) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00330 Arginine and proline metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.50.970 - - - 20 206 1.6E-55
Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain 31 199 2.4E-53
Gene3D G3DSA:3.40.50.1220 - - - 216 384 5.5E-38
SUPERFAMILY SSF52467 DHS-like NAD/FAD-binding domain IPR029035 DHS-like NAD/FAD-binding domain superfamily 184 377 3.27E-37
FunFam G3DSA:3.40.50.970:FF:000084 Probable 2-ketoarginine decarboxylase AruI - - 24 204 1.4E-119
PANTHER PTHR18968 THIAMINE PYROPHOSPHATE ENZYMES IPR045229 Thiamine pyrophosphate enzyme 29 553 2.4E-124
CDD cd07035 TPP_PYR_POX_like - - 34 190 3.6821E-59
Pfam PF00205 Thiamine pyrophosphate enzyme, central domain IPR012000 Thiamine pyrophosphate enzyme, central domain 221 350 2.6E-28
Gene3D G3DSA:3.40.50.970 - - - 385 558 4.9E-39
Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain IPR011766 Thiamine pyrophosphate enzyme, TPP-binding 414 552 1.1E-27
CDD cd00568 TPP_enzymes - - 388 554 3.50038E-46
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 386 557 7.51E-42
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 22 204 3.49E-53

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.