Pseudomonas aeruginosa PAO1, PA5111 (gloA3)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0006090	pyruvate metabolic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Biological Process	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	17513180	Reviewed by curator
Molecular Function	GO:0004462	lactoylglutathione lyase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	17513180	Reviewed by curator
Molecular Function	GO:0008270	zinc ion binding	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	17513180	Reviewed by curator
Molecular Function	GO:0003961	O-acetylhomoserine aminocarboxypropyltransferase activity	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0046872	metal ion binding	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00068	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004462	lactoylglutathione lyase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00068	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Central intermediary metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00620	Pyruvate metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Pyruvate metabolism		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Gene3D	G3DSA:3.10.180.10	-	IPR029068	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	2	169	7.7E-63
Pfam	PF00903	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	IPR004360	Glyoxalase/fosfomycin resistance/dioxygenase domain	24	164	1.5E-23
CDD	cd07233	GlxI_Zn	-	-	24	165	9.05357E-86
NCBIfam	TIGR00068	JCVI: lactoylglutathione lyase	IPR004361	Glyoxalase I	24	168	2.1E-63
SUPERFAMILY	SSF54593	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	IPR029068	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	9	167	2.82E-37
PANTHER	PTHR10374	LACTOYLGLUTATHIONE LYASE GLYOXALASE I	-	-	4	169	6.3E-75

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.