Pseudomonas aeruginosa PAO1, PA5331 (pyrE)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0004588	orotate phosphoribosyltransferase activity	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	25917504	Reviewed by curator
Biological Process	GO:0006221	pyrimidine nucleotide biosynthetic process	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	25917504	Reviewed by curator
Molecular Function	GO:0004588	orotate phosphoribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity Term mapped from: UniProtKB:P0A7E3	ECO:0000250 sequence similarity evidence used in manual assertion	9222315	Reviewed by curator
Biological Process	GO:0006221	pyrimidine nucleotide biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	8501045	Reviewed by curator
Molecular Function	GO:0004588	orotate phosphoribosyltransferase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01208	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006221	pyrimidine nucleotide biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01208	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Pyrimidine metabolism		ECO:0000037 not_recorded
KEGG	pae00240	Pyrimidine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	PWY-5686	UMP biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PRPP-PWY	superpathway of histidine, purine, and pyrimidine biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PWY0-162	superpathway of pyrimidine ribonucleotides de novo biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
PANTHER	PTHR46683	OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED	-	-	1	213	2.8E-87
CDD	cd06223	PRTases_typeI	IPR000836	Phosphoribosyltransferase domain	49	166	4.30606E-13
NCBIfam	TIGR00336	JCVI: orotate phosphoribosyltransferase	IPR004467	Orotate phosphoribosyl transferase domain	11	186	2.2E-61
Gene3D	G3DSA:3.40.50.2020	-	IPR029057	Phosphoribosyltransferase-like	1	213	8.4E-82
FunFam	G3DSA:3.40.50.2020:FF:000008	Orotate phosphoribosyltransferase	-	-	1	213	4.8E-105
SUPERFAMILY	SSF53271	PRTase-like	IPR029057	Phosphoribosyltransferase-like	1	211	3.98E-50
Pfam	PF00156	Phosphoribosyl transferase domain	IPR000836	Phosphoribosyltransferase domain	45	158	2.8E-9
Hamap	MF_01208	Orotate phosphoribosyltransferase [pyrE].	IPR023031	Orotate phosphoribosyltransferase	1	213	36.027992

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.