Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_05520
|
Name |
mexR
|
Replicon | chromosome |
Genomic location | 486057 - 486500 (- strand) |
Transposon Mutants in orthologs | 3 transposon mutants in orthologs |
RefSeq | YP_788598.1 |
GI | 116054155 |
Entrez | 4384292 |
INSDC | ABJ15391.1 |
NCBI Locus Tag | PA14_05520 |
UniParc | UPI00000061D9 |
UniProtKB Acc | Q02TY8 |
UniProtKB ID | Q02TY8_PSEAB |
UniRef100 | UniRef100_W0YLI3 |
UniRef50 | UniRef50_P52003 |
UniRef90 | UniRef90_P52003 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
multidrug resistance operon repressor MexR
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -4.65 |
Kyte-Doolittle Hydrophobicity Value | -0.407 |
Molecular Weight (kDa) | 17.0 |
Isoelectric Point (pI) | 5.57 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexR | MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. [PMID:14526032, PMID:12727072, PMID:20616806, PMID:18812515] | ARO:3000506 | protein overexpression model | Strict | 292.4 | 99.32 | 3.2.5 |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
3MEX | Transcription, Transcription Regulation | 04/01/10 | Crystal structure of MexR in oxidized state | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 98.6 |
4ZZL | TRANSCRIPTION | 04/10/15 | MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression | PSEUDOMONAS AERUGINOSA | 2.19 | X-RAY DIFFRACTION | 98.5 |
1LNW | TRANSCRIPTION REPRESSOR | 05/03/02 | CRYSTAL STRUCTURE OF THE MEXR REPRESSOR OF THE MEXAB-OPRM MULTIDRUG EFFLUX OPERON OF PSEUDOMONAS AERUGINOSA | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 99.3 |
3ECH | Transcription, Transcription regulation | 08/30/08 | The MarR-family repressor MexR in complex with its antirepressor ArmR | Pseudomonas aeruginosa | 1.802 | X-RAY DIFFRACTION | 97.9 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 244 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000415 (299 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_05520
Search term: mexR
Search term: multidrug resistance operon repressor MexR
|