Pseudomonas aeruginosa UCBPP-PA14, PA14_08620 (birA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006355 regulation of transcription, DNA-templated
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00978
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0036211 protein modification process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03099
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00121
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00780 Biotin metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc lipoate biosynthesis and incorporation (yeast) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc lipoate biosynthesis and incorporation III (Bacillus) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR12835 BIOTIN PROTEIN LIGASE - - 6 304 1.9E-53
SUPERFAMILY SSF46785 Winged helix DNA-binding domain IPR036390 Winged helix DNA-binding domain superfamily 3 55 4.62E-10
Gene3D G3DSA:2.30.30.100 - - - 263 312 1.3E-10
SUPERFAMILY SSF50037 C-terminal domain of transcriptional repressors IPR008988 Transcriptional repressor, C-terminal 263 309 1.28E-6
Pfam PF03099 Biotin/lipoate A/B protein ligase family IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain 80 201 9.5E-22
NCBIfam TIGR00121 JCVI: biotin--[acetyl-CoA-carboxylase] ligase IPR004408 Biotin--acetyl-CoA-carboxylase ligase 73 308 3.4E-56
Pfam PF08279 HTH domain IPR013196 Helix-turn-helix, type 11 2 54 1.2E-8
CDD cd16442 BPL IPR004408 Biotin--acetyl-CoA-carboxylase ligase 77 244 6.79034E-64
Gene3D G3DSA:1.10.10.10 - IPR036388 Winged helix-like DNA-binding domain superfamily 1 59 1.7E-19
Gene3D G3DSA:3.30.930.10 Bira Bifunctional Protein; Domain 2 IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) 65 261 9.1E-62
Hamap MF_00978 Bifunctional ligase/repressor BirA [birA]. IPR030855 Bifunctional ligase/repressor BirA 1 309 32.81765
SUPERFAMILY SSF55681 Class II aaRS and biotin synthetases IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) 71 260 8.7E-60

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.