Pseudomonas aeruginosa UCBPP-PA14, PA14_16070 (hom)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009088 threonine biosynthetic process
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA3736
 ECO:0000249
sequence similarity evidence used in automatic assertion		 10220164
Molecular Function GO:0004412 homoserine dehydrogenase activity
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA3736
 ECO:0000249
sequence similarity evidence used in automatic assertion		 10220164
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03447
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03447
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006520 cellular amino acid metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000098
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004412 homoserine dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000098
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau00300 Lysine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00270 Cysteine and methionine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF03447 Homoserine dehydrogenase, NAD binding domain IPR005106 Aspartate/homoserine dehydrogenase, NAD-binding 10 127 2.3E-25
PIRSF PIRSF000098 Homoser_dh IPR016204 Homoserine dehydrogenase 1 433 0.0
SUPERFAMILY SSF55021 ACT-like IPR045865 ACT-like domain 350 420 2.41E-15
Gene3D G3DSA:3.40.50.720 - - - 4 338 0.0
FunFam G3DSA:3.30.70.260:FF:000030 Homoserine dehydrogenase - - 347 422 1.2E-35
CDD cd04881 ACT_HSDH-Hom - - 352 431 5.17759E-30
Gene3D G3DSA:3.30.70.260 - - - 347 422 0.0
Pfam PF00742 Homoserine dehydrogenase IPR001342 Homoserine dehydrogenase, catalytic 135 313 7.2E-63
Pfam PF01842 ACT domain IPR002912 ACT domain 352 419 3.7E-16
PANTHER PTHR43331 HOMOSERINE DEHYDROGENASE - - 1 321 9.0E-114
FunFam G3DSA:3.30.360.10:FF:000005 Homoserine dehydrogenase - - 134 302 2.2E-71
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 1 156 5.33E-36
Gene3D G3DSA:3.30.360.10 Dihydrodipicolinate Reductase; domain 2 - - 134 346 0.0
SUPERFAMILY SSF55347 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain - - 135 300 1.5E-52

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.